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  <xsd:element abstract="true" id="pbyi_Customer2Member" name="Customer2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_Customer3Member" name="Customer3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_Customer4Member" name="Customer4Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_Customer5Member" name="Customer5Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_CustomersWithMoreThan10AccountsReceivableMember" name="CustomersWithMoreThan10AccountsReceivableMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_DebtInstrumentExitPayment" name="DebtInstrumentExitPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_DebtInstrumentExitPaymentPercent" name="DebtInstrumentExitPaymentPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_DebtInstrumentPeriodicPaymentExitPayment" name="DebtInstrumentPeriodicPaymentExitPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_DebtInstrumentPeriodicPaymentExitPaymentPercent" name="DebtInstrumentPeriodicPaymentExitPaymentPercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsGross" name="DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsGross" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_DeferredTaxAssetLeaseLiabilities" name="DeferredTaxAssetLeaseLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_DeferredTaxAssetsAccruedLegalVerdict" name="DeferredTaxAssetsAccruedLegalVerdict" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_DeferredTaxAssetsBusinessCreditCarryforward" name="DeferredTaxAssetsBusinessCreditCarryforward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_DeferredTaxAssetsValuationAllowancePortionReleasedDecreaseInTaxRate" name="DeferredTaxAssetsValuationAllowancePortionReleasedDecreaseInTaxRate" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_DeferredTaxLiabilitiesAssetsInventory" name="DeferredTaxLiabilitiesAssetsInventory" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="pbyi_DocumentAndEntityInformation" name="DocumentAndEntityInformation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_EffectiveIncomeTaxRateReconciliationDeductionCoveredEmployeeAmount" name="EffectiveIncomeTaxRateReconciliationDeductionCoveredEmployeeAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_EffectiveIncomeTaxRateReconciliationDeductionCoveredEmployeePercent" name="EffectiveIncomeTaxRateReconciliationDeductionCoveredEmployeePercent" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_EmployeeAndNonemployeeStockOptionMember" name="EmployeeAndNonemployeeStockOptionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_EmploymentInducementIncentiveAwardPlanTwentySeventeenMember" name="EmploymentInducementIncentiveAwardPlanTwentySeventeenMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_EquityIncentivePlanTwentyElevenMember" name="EquityIncentivePlanTwentyElevenMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_First3OfEachParticipantsContributionsMember" name="First3OfEachParticipantsContributionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_ForecastedEarningsInUpcomingYearMember" name="ForecastedEarningsInUpcomingYearMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_IncomeTaxBenefitDueToResearchAndDevelopmentTaxCredits" name="IncomeTaxBenefitDueToResearchAndDevelopmentTaxCredits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_IncreaseDecreaseInOperatingLeaseAssetsAndLiabilitiesNet" name="IncreaseDecreaseInOperatingLeaseAssetsAndLiabilitiesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_IncreaseDecreaseInPostmarketingCommitmentLiability" name="IncreaseDecreaseInPostmarketingCommitmentLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_IndianaDepartmentOfRevenueMember" name="IndianaDepartmentOfRevenueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_KentuckyDepartmentOfRevenueMember" name="KentuckyDepartmentOfRevenueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_LeaseAgreementOneMember" name="LeaseAgreementOneMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_LeaseAgreementTwoMember" name="LeaseAgreementTwoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_LeaseOptionToExtendTerm" name="LeaseOptionToExtendTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_LesseeOperatingLeasesRelatedToSupplementalCashFlowInformationTableTextBlock" name="LesseeOperatingLeasesRelatedToSupplementalCashFlowInformationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_LicenseFeesAndIntangibleAssetsPolicyTextBlock" name="LicenseFeesAndIntangibleAssetsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_MedicalAffairsMember" name="MedicalAffairsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_MilestonePayment" name="MilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_MilestonePaymentsMaximumAmount" name="MilestonePaymentsMaximumAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="pbyi_NerlynxMember" name="NerlynxMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_NonvestedStockOptionsMember" name="NonvestedStockOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_NotePurchaseAgreementMember" name="NotePurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_NumberOfMajorCustomers" name="NumberOfMajorCustomers" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_NumberOfSubsidiaries" name="NumberOfSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_OrdinarySharesOwnershipPercentage" name="OrdinarySharesOwnershipPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="pbyi_OtherResearchAndDevelopmentMember" name="OtherResearchAndDevelopmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_OxfordFinanceLimitedLiabilityCompanyMember" name="OxfordFinanceLimitedLiabilityCompanyMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_PennsylvaniaDepartmentOfRevenueMember" name="PennsylvaniaDepartmentOfRevenueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_PercentageOfAnnualRentIncrement" name="PercentageOfAnnualRentIncrement" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_PercentageOfUnpaidPortionOfMilestonePaymentsInterestRate" name="PercentageOfUnpaidPortionOfMilestonePaymentsInterestRate" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_PfizerLicenseAgreementMember" name="PfizerLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_PolicyTable" name="PolicyTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_PostMarketingCommitmentLiabilityCurrent" name="PostMarketingCommitmentLiabilityCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_PostmarketingCommitmentLiabilityNoncurrent" name="PostmarketingCommitmentLiabilityNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_PotentialMilestonePayments" name="PotentialMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_PrepaidCROServicesCurrent" name="PrepaidCROServicesCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_PrepaidCROServicesNoncurrent" name="PrepaidCROServicesNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_PrepaidExpenseAndOtherAssetsTableTextBlock" name="PrepaidExpenseAndOtherAssetsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_PrepaidExpenseAndOtherAssetsTextBlock" name="PrepaidExpenseAndOtherAssetsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_PrepaidInsuranceNoncurrent" name="PrepaidInsuranceNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_PrepaidOtherClinicalDevelopmentCurrent" name="PrepaidOtherClinicalDevelopmentCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_PrepaidOtherClinicalDevelopmentExpenseNoncurrent" name="PrepaidOtherClinicalDevelopmentExpenseNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_PrepaidProfessionalFessCurrent" name="PrepaidProfessionalFessCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="pbyi_ReclassifiedToNoncashItemsMember" name="ReclassifiedToNoncashItemsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_RoyaltiesPolicyPolicyTextBlock" name="RoyaltiesPolicyPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_RoyaltyRevenueReceivable" name="RoyaltyRevenueReceivable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="pbyi_ScheduleOfAccountsReceivableTableTextBlock" name="ScheduleOfAccountsReceivableTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_ScheduleOfCashTaxesPaidTableTextBlock" name="ScheduleOfCashTaxesPaidTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_ScheduleOfDeferredFinancingCostsTableTextBlock" name="ScheduleOfDeferredFinancingCostsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_SecondTwoPercentOfEachParticipantsContributionsMember" name="SecondTwoPercentOfEachParticipantsContributionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_SecuredPromissoryNotesMember" name="SecuredPromissoryNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsInitialContractualTerm" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsInitialContractualTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_SouthKoreanNationalTaxServiceMember" name="SouthKoreanNationalTaxServiceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_StockBasedCompensationMember" name="StockBasedCompensationMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_SubleaseAgreementPotentialMilestonePayments" name="SubleaseAgreementPotentialMilestonePayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="pbyi_TakedaLicenseAgreementMember" name="TakedaLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_TakedaMember" name="TakedaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_TelephoneEquipmentMember" name="TelephoneEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_TerminationNoticePeriod" name="TerminationNoticePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_The2011And2017PlansMember" name="The2011And2017PlansMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_TradeAccountsReceivableNetExcludingLicenseRevenueReceivable" name="TradeAccountsReceivableNetExcludingLicenseRevenueReceivable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="pbyi_UnvestedRestrictedStockUnitsMember" name="UnvestedRestrictedStockUnitsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="pbyi_UpfrontLicenseFee" name="UpfrontLicenseFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-10-stockholders-equity-options-award-assumptions-details" name="statement-statement-note-10-stockholders-equity-options-award-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-10-stockholders-equity-restricted-stock-units-details" name="statement-statement-note-10-stockholders-equity-restricted-stock-units-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-10-stockholders-equity-stock-option-activity-details" name="statement-statement-note-10-stockholders-equity-stock-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-10-stockholders-equity-stockbased-compensation-expense-details" name="statement-statement-note-10-stockholders-equity-stockbased-compensation-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-10-stockholders-equity-tables" name="statement-statement-note-10-stockholders-equity-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-12-income-taxes-cash-taxes-paid-details" name="statement-statement-note-12-income-taxes-cash-taxes-paid-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-12-income-taxes-components-of-net-deferred-tax-assets-details" name="statement-statement-note-12-income-taxes-components-of-net-deferred-tax-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-12-income-taxes-reconciliation-of-unrecognized-tax-benefits-details" name="statement-statement-note-12-income-taxes-reconciliation-of-unrecognized-tax-benefits-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-12-income-taxes-schedule-of-income-before-income-taxes-details" name="statement-statement-note-12-income-taxes-schedule-of-income-before-income-taxes-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-12-income-taxes-schedule-of-income-tax-expense-details" name="statement-statement-note-12-income-taxes-schedule-of-income-tax-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-12-income-taxes-schedule-of-income-tax-reconciliation-details" name="statement-statement-note-12-income-taxes-schedule-of-income-tax-reconciliation-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-12-income-taxes-tables" name="statement-statement-note-12-income-taxes-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-2-significant-accounting-policies-assets-measured-at-fair-value-on-recurring-basis-details" name="statement-statement-note-2-significant-accounting-policies-assets-measured-at-fair-value-on-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-2-significant-accounting-policies-inventory-balance-details" name="statement-statement-note-2-significant-accounting-policies-inventory-balance-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-2-significant-accounting-policies-potentially-dilutive-securities-not-included-in-calculation-of-diluted-net-loss-per-share-details" name="statement-statement-note-2-significant-accounting-policies-potentially-dilutive-securities-not-included-in-calculation-of-diluted-net-loss-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-2-significant-accounting-policies-segment-information-details" name="statement-statement-note-2-significant-accounting-policies-segment-information-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-2-significant-accounting-policies-summary-of-cash-equivalents-and-shortterm-investment-details" name="statement-statement-note-2-significant-accounting-policies-summary-of-cash-equivalents-and-shortterm-investment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-2-significant-accounting-policies-tables" name="statement-statement-note-2-significant-accounting-policies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-3-accounts-receivable-net-schedule-of-accounts-receivable-net-details" name="statement-statement-note-3-accounts-receivable-net-schedule-of-accounts-receivable-net-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-3-accounts-receivable-net-tables" name="statement-statement-note-3-accounts-receivable-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-4-prepaid-expenses-and-other-prepaid-expenses-and-other-details" name="statement-statement-note-4-prepaid-expenses-and-other-prepaid-expenses-and-other-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-4-prepaid-expenses-and-other-tables" name="statement-statement-note-4-prepaid-expenses-and-other-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-5-property-and-equipment-property-and-equipment-details" name="statement-statement-note-5-property-and-equipment-property-and-equipment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-5-property-and-equipment-tables" name="statement-statement-note-5-property-and-equipment-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-6-leases-future-minimum-lease-payments-to-be-received-details" name="statement-statement-note-6-leases-future-minimum-lease-payments-to-be-received-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-6-leases-future-minimum-lease-payments-under-asc-842-details" name="statement-statement-note-6-leases-future-minimum-lease-payments-under-asc-842-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-6-leases-supplemental-cash-flow-information-related-to-leases-details" name="statement-statement-note-6-leases-supplemental-cash-flow-information-related-to-leases-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-6-leases-tables" name="statement-statement-note-6-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-7-intangible-assets-future-amortization-expense-maturity-details" name="statement-statement-note-7-intangible-assets-future-amortization-expense-maturity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-7-intangible-assets-intangible-assets-details" name="statement-statement-note-7-intangible-assets-intangible-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-7-intangible-assets-tables" name="statement-statement-note-7-intangible-assets-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-8-accrued-expenses-composition-of-current-and-longterm-accrued-expenses-details" name="statement-statement-note-8-accrued-expenses-composition-of-current-and-longterm-accrued-expenses-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-8-accrued-expenses-tables" name="statement-statement-note-8-accrued-expenses-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-9-debt-future-minimum-principal-payments-details" name="statement-statement-note-9-debt-future-minimum-principal-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-9-debt-schedule-of-debt-issuance-costs-and-discounts-details" name="statement-statement-note-9-debt-schedule-of-debt-issuance-costs-and-discounts-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-9-debt-schedule-of-long-term-debt-details" name="statement-statement-note-9-debt-schedule-of-long-term-debt-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-9-debt-schedule-of-long-term-debt-details-parentheticals" name="statement-statement-note-9-debt-schedule-of-long-term-debt-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-note-9-debt-tables" name="statement-statement-note-9-debt-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="pbyi_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
